^

EMG Supports the Research into GRIN Disorders

What are GRIN disorders?

GRIN Disorders are rare genetic conditions with severe life-limiting consequences. Many GRIN patients are non-verbal, unable to walk, and many cannot feed or toilet themselves. They often suffer severe and frequent seizures that are not responsive to medical therapies. 

GRIN Disorders are caused by a change in one of seven GRIN genes including GRIN1, GRIN2A, GRIN2B, and GRIN2D. These genes contain the code to create NMDA receptors, which are essential for learning and memory.  Most cases are de novo (not inherited from the parent) missense mutations where a single letter is “misspelled” among the 3.2-billion letters of human DNA.

Diagnosing GRIN1, GRIN2A, GRIN2B, and GRIN2D

Parents of children with GRIN Disorders typically notice that something is wrong when infants begin missing milestones. GRIN Disorders are usually diagnosed by genetic testing called Genome sequencing. As genetic tests become more affordable, it is increasingly common for children to be diagnosed before the age of two. However, without a genetic diagnosis, some individuals are incorrectly diagnosed with cerebral palsy, autism or another genetic disorder such as Angelman Syndrome.

Most common symptoms of GRIN Disorders​

  • developmental delay 
  • intellectual disability
  • epilepsy (seizures)
  • hypotonia (low tone)
  • constipation (GI Issues)
  • limited or non-verbal communication
  • cortical visual impairment (CVI)
  • dystonia 
  • sleep disorders 
  • feeding difficulties 
  • limited mobility
  • autism

What we do

Our EMG community has selected a rare genetic disease as a key target to our company involvement: Grin2B. This deviation only affects a small group of children and adults, but the effect can be huge to their lives.

We decided to allocate 10% of our profits to research and parent support. Our funding enabled a researcher, doctor Xavier Altafaj Tardillo, with research institution Idibell in Barcelona, to conduct several studies – one, for example, into the effect of generic approved drugs on Grin related disorders.

EMG builds bridges between business relations, researchers and medical professionals as a non-monetary contribution.

Learn more about Grin2B disorder here


Global HR & Mobility Market Updates

The Latest News on Remote Work, New U.K. Immigration Route and Immigration to Canada

– Encouraging Civility Among Remote Employees
– New U.K. Immigration Route for Hong Kong Nationals
– Canada’s Doors are Open, But Entry is Challenging in 2020

Read More

The Latest News on Canadian Visa Program, US Election and Covid-19

– Canadian visa program may lure tech workers blocked by Trump
– A top immigrant advocate on the US election
– COVID-19: Dutch State Secretary Extends Reporting Deadlines

Read More

The Latest News on COVID-19, Skill Gaps and American Workers

– COVID-19 has surfaced these skill gaps: now we need to fill them
– Employees Look to HR to Evaluate COVID-19 Data Before Reopening
– Judge Rules U.S. Companies Can Be Sued for Preferring U.S. Workers

Read More


We offer innovative, smart & sustainable solutions for any global mobility challenge, at transparent (value) pricing.

Browse our website and our portfolio of services,
see why EMG is your global mobility partner of choice.

Looking forward to providing a moving experience,
Nino Nelissen – Founder of EMG